Engineering spatial-organized cardiac organoids for developmental toxicity testing
نویسندگان
چکیده
منابع مشابه
Transcriptomics in developmental toxicity testing
Reproductive toxicity testing is one of the most complex, expensive and labor intensive fields of toxicology (Leist et al. drastically demonstrate the fundamental importance of reliable developmental toxicity tests for human safety (van Recently, human embryonic stem cell based in vitro test systems have been established that recapitulate critical periods of human early development (Krug et al....
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Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become deeply ingrained with some stereotyped behaviors with respect to such relevant issues as choice of a...
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Correspondence address: Assoc Prof. Eduard Ujházy, PhD. Department of Reproductive Toxicology, Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia, e-mail: [email protected] Studies of individual development and its possible deterioration have been the concern since the 19th century, when Etienne Geoffroy de Saint-Hilaire (1772...
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The use of experimental animals in reproductive toxicity testing is critically reviewed on the occasion of the 50th anniversary of the publication of the Three Rs concept by Russell and Burch, since there is major concern that reproductive toxicity testing will significantly increase due to the requirements of the EU Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) s...
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A review is presented of the use of developmental toxicity testing in the United States and international regulatory assessment of human health risks associated with exposures to pharmaceuticals (human and veterinary), chemicals (agricultural, industrial, and environmental), food additives, cosmetics, and consumer products. Developmental toxicology data are used for prioritization and screening...
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ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2021
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2021.03.013